The article presents the basic principles and provisions of oilfield chemistry at Gazprom Neft. The definition of the concept of "Petroleum chemistry", the place and role of this functional area in the production chain and the standardization system are given. The purpose of chemicalization is formulated - ensuring the stability and safety of the technological process involving the use of a chemical reagent, minimizing risks and reducing unit costs. Achievement of the goal is ensured by solving a whole range of tasks, among which are: analysis of objects and environments, targeted selection, control and accounting of consumption, analysis of the effectiveness of the use of reagents, increasing the level of personnel competencies, R&D and involvement in cross-functional projects. The basic principles on which the work on oilfield chemistry is based are given: safety, risk minimization, comprehensive assessment, targeting, efficiency, alternativeness and validity of the use of reagents. The components of the system for the use of chemical reagents in the Company are shown, including technological processes, equipment, personnel. General and specific requirements for chemical reagents are discussed. The process of selecting and admitting reagents for industrial use is discussed in detail, starting from the stage of analysis of a production facility, through laboratory and pilot tests. Approaches to carrying out laboratory tests with different initial conditions are outlined. The procedure of "controlled operation" is described - conducting pilot tests according to a simplified scheme. In the final part, some key indicators for evaluating the effectiveness of the chemicalization system are presented, grouped by production areas: downhole operations, artificial lift, collection, transportation, preparation of hydrocarbons and water.