The analysis of the dynamics of paleotectonic development of area, covering the eastern part of the Khanty-Mansi Autonomous Okrug, is executed. A set of isopach maps is drawn and analyzed, using a surface of the reference reflective seismic horizons A, B, and G, corresponding to the boundaries of the basic structural-formational megacomplexes of sedimentary cover and the surface of pre-Jurassic formations. The main stages in the formation of the topography of the eastern part of Khanty-Mansi Autonomous Okrug and the basic regularities of oil and gas content are revealed.