The article provides an overview of the requirements of the Gazprom Neft Company to chemical reagents for hydrocarbon production processes, and substantiates the boundaries of the scope of application of the requirements. The concept of "oilfield chemicals" is established as used in the processes of production intensification, well killing, well fluid lifting, field gathering and preparation of oil, maintaining reservoir pressure, transportation of commercial oil. Discussed topical issues related to the list and filling of technical and permitting documentation, its compliance with the updated edition of Russian state standard GOST 54567-2011 “Oil. Requirements for chemical products ensuring their safe use in the oil industry” and technical regulations TR EAEU 045/2017 “On the safety of oil prepared for transportation and (or) use”. The substantiation of the general requirements for reagents, practical approaches to ensuring their fulfillment during laboratory and field trials and incoming control for the purpose of admission to industrial use is given. The classification of standardized indicators, their division by functional purpose into physicochemical, technological and compatibility is discussed. Approaches to the determination of organic chlorides in chemical reagents, the disadvantages of known and currently used methods are discussed, specific recommendations are given for assessing the effect of reagents on the content of organic chlorides in oil, including during the formation of the latter during the interaction of reagent components and oil. The nuances of the indicators "mass fraction of the active base", "efficiency", issues of physicochemical and technological compatibility with oilfield media - water, oil, killing fluids are discussed. An approach to determining the requirements for new types of reagents is presented, examples of specific indicators and recommendations for their numerical standardization are given.