Key words: modeling, Bolshehetskaya depression, forecast of oil and gas content, generation.Article examines oil and gas potential of Bolshekhetskaya depression, based on studies of geothermobaric and geochemical conditions of formation of oil and gas accumulations and modeling hydrocarbon systems. As follows from the studies, warming sedimentary rocks in the pool was evenly until the Neogene erosion and controlled by climate change and heat flow from the base. During the erosion temperature of lower section got down slightly. For example, before Neogene erosion temperature in the model bottom (Megion layer, Upper Jurassic) reached 140 °C (in deepest part of the basin). At the end of the Neogene erosion temperature fell to an average of 110 °С. Excess pressure formed during the intense subsidence and rapid sedimentation. There were two such periods: in the Eocene (50-40 Ma) and early Miocene (20-10 Ma). According to the results of thermobaric analysis the authors synthesized maturation model of organic matter in source rocks, as well as migration and accumulation of hydrocarbons. The most promising structures for further study and exploration and rationale for these conclusions were identified.